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By increasing your dose slowly over time (under your doctors guidance), staying hydrated, and adjusting your eating habits, you can successfully minimize discomfort while achieving your long-term health goals

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The occluded aqueous cavity housing the Na + -binding site is unusual, and we hypothesise that Na + binding and ordering of solvent within this cavity may stabilise the N-terminal domain and contribute to transporter gating

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10.1016/j.bcp.2018.01.040 12 GasbjergL